Article
Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway.
Somatic cell and molecular genetics - 1 May 1997
Bulla G A
Abstract excerpt
Liver-enriched trans-acting factors hepatocyte nuclear factor-1 alpha (HNF1 alpha) and -4 (HNF4) are components of a transcriptional activation pathway that is thought to play a major role in hepatic gene activation. We previously described the isolation and characterization of distinct classes of hepatoma variants which lack the HNF4-->HNF1 alpha pathway (1). In order to determine the influence of the...
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