Article
Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway.
Somatic cell and molecular genetics - 1 May 1997
Bulla G A
Abstract excerpt
Liver-enriched trans-acting factors hepatocyte nuclear factor-1 alpha (HNF1 alpha) and -4 (HNF4) are components of a transcriptional activation pathway that is thought to play a major role in hepatic gene activation. We previously described the isolation and characterization of distinct classes o...
Topics
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Carcinoma, Hepatocellular
- Cell Line
- Chromosomes, Human
- DNA-Binding Proteins
- Fibroblasts
- Gene Expression Regulation
- Gene Transfer Techniques
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 4
- Humans
- Hybrid Cells
- Liver
- Mice
- Nuclear Proteins