Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.

Molecular and cellular biology - 1 Feb 2001

Hayhurst G P, Lee Y H, Lambert G, Ward J M, Gonzalez F J

Abstract excerpt

The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enriched transcription factors (hepatocyte nuclear factor 1alpha [HNF1alpha], -1beta, -3alpha, -3beta, -3gamma, -4alpha, and -6 and members of the c/ebp family). Of these, only HNF4alpha (nuclear receptor 2A1) and HNF1alpha appear to be correlated with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Bile Acids and Salts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Biological Transport, Active

Share to Gene Targeting

Share to Hepatocyte Nuclear Factor 4

Share to Hepatomegaly

Share to Lipid Metabolism

Share to Receptors, Cytoplasmic and Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 11158324
DOI: 10.1128/MCB.21.4.1393-1403.2001
PMCID: PMC99591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis.PMID 11158324Read ↗

HNF4α in Hepatocyte Health and DiseaseSemantic proximity Read ↗

Hepatocyte Nuclear Factor 4 Alpha: A Key Regulator of Liver Disease Pathology and Haemostatic DisordersSemantic proximity Read ↗

Human Hepatocyte Nuclear Factor 4 Isoforms Are Encoded by Distinct and Differentially Expressed GenesSemantic proximity Read ↗

Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice.Semantic proximity Read ↗

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta.Semantic proximity Read ↗

The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesisSemantic proximity Read ↗

HNF4α isoforms: the fraternal twin master regulators of liver functionSemantic proximity Read ↗

Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseasesSemantic proximity Read ↗

The molecular functions of hepatocyte nuclear factors - In and beyond the liver.Semantic proximity Read ↗

Hepatic circadian and differentiation factors control liver susceptibility for fatty liver disease and tumorigenesisSemantic proximity Read ↗

The role of hepatocyte nuclear factor 1β in disease and development.Semantic proximity Read ↗

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.