Article
Hepatocyte nuclear factor 4 expression overcomes repression of the hepatic phenotype in dedifferentiated hepatoma cells.
Molecular and cellular biology - 1 Apr 1997
Späth G F, Weiss M C
Abstract excerpt
The capacity of the liver-enriched transcription factor hepatocyte nuclear factor 4 (HNF4) to direct redifferentiation of dedifferentiated rat hepatoma cells was investigated by stable transfection of epitope-tagged HNF4 cDNA into H5 variant cells. HNF4-producing cells expressed the previously si...
Topics
- Animals
- Azacitidine
- Base Sequence
- Cell Differentiation
- DNA Methylation
- DNA, Complementary
- DNA-Binding Proteins
- Dexamethasone
- Gene Expression
- Genetic Markers
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 4
- Liver
- Liver Neoplasms, Experimental
- Nuclear Proteins
- Phenotype