Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells.

doi:10.1093/mutage/9.3.253

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Article

Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells.

Mutagenesis - 1 May 1994

Wang T S, Huang H

Abstract excerpt

The human carcinogen, arsenic, is genotoxic to mammalian cells in vitro. The mechanism is largely unknown, although the involvement of free radicals has been suggested. Since the X-ray sensitive Chinese hamster ovary cell line, XRS-5, is also sensitive to several free-radical generating agents, i...

Topics

Animals
Arsenites
CHO Cells
Catalase
Cricetinae
Glutathione
Glutathione Transferase
Hydrogen Peroxide
Micronuclei, Chromosome-Defective
Micronucleus Tests
Mutation
Radiation Tolerance
Reactive Oxygen Species

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