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Menadione-resistant Chinese hamster cell variants are cross-resistant to hydrogen peroxide and exhibit stable chromosomal and biochemical alterations.

Molecular and cellular biochemistry - 16 Dec 1992

Martins E A, Mori L, Birnboim H C, Meneghini R

Abstract excerpt

We have investigated the antioxidant properties of V79 Chinese hamster cells rendered resistant to menadione by chronic exposure to increasing concentrations of this quinone. MD1, a clone of resistant cells, was compared to the parental M8 cells; the former showed increased activity of catalase (3 fold), glutathione peroxidase (1.6 fold) and DT-diaphorase (2.6 fold), as well as an increase in glutathione (3.2...

Topics

Animals
CHO Cells
Catalase
Chromosome Aberrations
Clone Cells
Cricetinae
Dihydrolipoamide Dehydrogenase
Drug Resistance
Glutathione
Glutathione Peroxidase
Hydrogen Peroxide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Vitamin K

Source

Identifiers

PMID: 1293512
DOI: 10.1007/BF00299397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1293512-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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