Radiation induced bystander signals are independent of DNA damage and DNA repair capacity of the irradiated cells.

doi:10.1016/j.mrfmmm.2007.02.005

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Article

Radiation induced bystander signals are independent of DNA damage and DNA repair capacity of the irradiated cells.

Mutation research - 1 Jun 2007

Kashino Genro, Suzuki Keiji, Matsuda Naoki, Kodama Seiji, Ono Koji, Watanabe Masami, Prise Kevin M

Abstract excerpt

Evidence is accumulating that irradiated cells produce signals, which interact with non-exposed cells in the same population. Here, we analysed the mechanism for bystander signal arising in wild-type CHO cells and repair deficient varients, focussing on the relationship between DNA repair capacity and bystander signal arising in irradiated cells. In order to investigate the bystander effect, we carried out medium...

Topics

Animals
CHO Cells
Cricetinae
Cricetulus
DNA Damage
DNA Repair
Micronucleus Tests
Mutation
Signal Transduction

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Identifiers

PMID: 17395217
DOI: 10.1016/j.mrfmmm.2007.02.005
PMCID: PMC3004241

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