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Sodium arsenite enhances the cytotoxicity, clastogenicity, and 6-thioguanine-resistant mutagenicity of ultraviolet light in Chinese hamster ovary cells.

Mutation research - 1 Jan 2000

Lee T C, Huang R Y, Jan K Y

Abstract excerpt

Cytotoxicity, chromosome aberrations, and mutations to 6-thioguanine resistance were synergistically increased by incubating the ultraviolet light (UV)-irradiated Chinese hamster ovary (CHO) cells in medium containing sodium arsenite. However, the frequencies of sister-chromatid exchanges and mutations to ouabain resistance induced by UV were not synergistically increased by sodium arsenite. The synergistic...

Topics

Animals
Arsenic
Arsenites
Cell Survival
Chromosome Aberrations
Cricetinae
Cricetulus
Drug Resistance
Female
Mutation
Ouabain
Ovary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sister Chromatid Exchange

Thioguanine

Ultraviolet Rays

Source

Identifiers

PMID: 3969080
DOI: 10.1016/0027-5107(85)90210-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3969080-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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