Article
Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations.
Environmental and molecular mutagenesis - 1 Jan 2003
Kligerman Andrew D, Doerr Carolyn L, Tennant Alan H, Harrington-Brock Karen, Allen James W, Winkfield Ernest, Poorman-Allen Patricia, Kundu Bijit, Funasaka Kunihiro, Roop Barbara C, Mass Marc J, DeMarini David M
Abstract excerpt
Arsenic is a prevalent human carcinogen whose mutagenicity has not been characterized fully. Exposure to either form of inorganic arsenic, As(III) or As(V), can result in the formation of at least four organic metabolites: monomethylarsonic acid, monomethylarsonous acid (MMA(III)), dimethylarsinic acid, and dimethylarsinous acid (DMA(III)). The methylated trivalent species, as well as some of the other species,...
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