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Molecular analysis of reactive oxygen-species-induced mammalian gene mutation.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1990

Hsie A W, Xu Z D, Yu Y J, Sognier M A, Hrelia P

Abstract excerpt

We have studied the mutagenicity and toxicity of physical and chemical agents in the Chinese hamster ovary (CHO) cell line K1-BH4 and its transformant, AS52. The AS52 cells lack the normal X-linked mammalian hypoxanthine-guanine phosphoribosyltransferase (hprt) gene but instead contain a single autosomally integrated copy of the bacterial equivalent, the xanthine-guanine phosphoribosyltransferase (gpt) gene. We...

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Identifiers

PMID: 1973850
DOI: 10.1002/tcm.1770100207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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