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Article

Molecular analysis of reactive oxygen-species-induced mammalian gene mutation.

Teratogenesis, carcinogenesis, and mutagenesis - 1 Jan 1990

Hsie A W, Xu Z D, Yu Y J, Sognier M A, Hrelia P

Abstract excerpt

We have studied the mutagenicity and toxicity of physical and chemical agents in the Chinese hamster ovary (CHO) cell line K1-BH4 and its transformant, AS52. The AS52 cells lack the normal X-linked mammalian hypoxanthine-guanine phosphoribosyltransferase (hprt) gene but instead contain a single autosomally integrated copy of the bacterial equivalent, the xanthine-guanine phosphoribosyltransferase (gpt) gene. We...

Topics

Animals
Cell Line
Chromosome Deletion
Cricetinae
Cricetulus
Hypoxanthine Phosphoribosyltransferase
Mutagens
Mutation
Oxygen
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1973850
DOI: 10.1002/tcm.1770100207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1973850-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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