Article
Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998
Hei T K, Liu S X, Waldren C
Abstract excerpt
Arsenite, the trivalent form of arsenic present in the environment, is a known human carcinogen that lacked mutagenic activity in bacterial and standard mammalian cell mutation assays. We show herein that when evaluated in an assay (AL cell assay), in which both intragenic and multilocus mutation...
Topics
- Animals
- Arsenic
- CHO Cells
- Chromosomes, Human, Pair 11
- Cricetinae
- Humans
- Hybrid Cells
- Mutagenicity Tests
- Mutation
- Reactive Oxygen Species