Article
Age- and temperature-dependent somatic mutation accumulation in Drosophila melanogaster.
PLoS genetics - 13 May 2010
Garcia Ana Maria, Calder R Brent, Dollé Martijn E T, Lundell Martha, Kapahi Pankaj, Vijg Jan
Abstract excerpt
Using a transgenic mouse model harboring a mutation reporter gene that can be efficiently recovered from genomic DNA, we previously demonstrated that mutations accumulate in aging mice in a tissue-specific manner. Applying a recently developed, similar reporter-based assay in Drosophila melanogaster, we now show that the mutation frequency at the lacZ locus in somatic tissue of flies is about three times as high...
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