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Article

Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha.

Cancer research - 15 Jun 1993

Hoffmann J S, Fry M, Ji J, Williams K J, Loeb L A

Abstract excerpt

Mutagenesis of protooncogenes has been postulated to contribute to the initiation and progression of human cancer. Activating mutations in the H-ras gene are predominantly single-base substitutions and are most frequently identified at codons 12, 13, and 61. We have analyzed the effects of DNA sequence context at specific codons that are hot spots for ras mutation with respect to abnormalities in copying by...

Topics

Base Sequence
Codon
DNA
DNA Polymerase II
DNA, Single-Stranded
Gene Amplification
Genes, ras
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Sequence Analysis, DNA

Source

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PMID: 8504430

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