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Article

Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.

Nature - 1 Jan 2000

Bos J L, Toksoz D, Marshall C J, Verlaan-de Vries M, Veeneman G H, van der Eb A J, van Boom J H, Janssen J W, Steenvoorden A C

Abstract excerpt

DNAs from four out of five patients with acute myeloid leukaemia (AML) tested by an in vivo selection assay in nude mice using transfected mouse NIH 3T3 cells were found to contain an activated N-ras oncogene. Using a set of synthetic oligonucleotide probes, we have detected a mutation at codon 13 in all four genes. The same codon is mutated in an additional AML DNA that is positive in the focus-formation assay...

Topics

Amino Acid Sequence
Aspartic Acid
Binding Sites
DNA Restriction Enzymes
Guanosine Triphosphate
Humans
Leukemia, Myeloid, Acute
Mutation
Oncogenes
Polymorphism, Genetic
Transfection

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Identifiers

PMID: 2989702
DOI: 10.1038/315726a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2989702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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