Altered host range phenotype of the transformation-defective Ad12 mutant CS-1 is due to deletions in the E1 region.

doi:10.1159/000150354

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Article

Altered host range phenotype of the transformation-defective Ad12 mutant CS-1 is due to deletions in the E1 region.

Intervirology - 1 Jan 1994

Opalka B, Reith-Witowski M, Kirch H C, Holthausen H S

Abstract excerpt

Although it grows well in bulk infection, human adenovirus type 12 (Ad12) does not plaque efficiently in Vero cells of simian origin. After long-term passage of the virus or after transfection of Ad12 DNA into these cells, however, transformation-defective, host-range mutants giving high plaque y...

Topics

Adenovirus E1 Proteins
Adenoviruses, Human
Animals
Chlorocebus aethiops
HeLa Cells
Humans
Phenotype
Sequence Deletion
Transfection
Vero Cells
Viral Plaque Assay

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