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Article

Altered host range phenotype of the transformation-defective Ad12 mutant CS-1 is due to deletions in the E1 region.

Intervirology - 1 Jan 1994

Opalka B, Reith-Witowski M, Kirch H C, Holthausen H S

Abstract excerpt

Although it grows well in bulk infection, human adenovirus type 12 (Ad12) does not plaque efficiently in Vero cells of simian origin. After long-term passage of the virus or after transfection of Ad12 DNA into these cells, however, transformation-defective, host-range mutants giving high plaque yields in Vero cells were isolated. The original mutants have deletions in both E1a and E1b as well as additions of...

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Identifiers

PMID: 7928288
DOI: 10.1159/000150354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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