Mutations of polyomavirus VP1 allow in vitro growth in undifferentiated cells and modify in vivo tissue replication specificity.

doi:10.1128/JVI.68.2.1196-1199.1994

Back to search

Article

Mutations of polyomavirus VP1 allow in vitro growth in undifferentiated cells and modify in vivo tissue replication specificity.

Journal of virology - 1 Feb 1994

Mezes B, Amati P

Abstract excerpt

Mutants of polyomavirus with altered host specificities were isolated in undifferentiated C2 myoblast cells (L. Ricci, R. Maione, C. Passananti, A. Felsani, and P. Amati, J. Virol. 66:7153-7158, 1992). The mutations responsible for this phenotype belonged to either of the two classes: a large dup...

Topics

Animals
Capsid
Capsid Proteins
Cell Differentiation
Cells, Cultured
Mice
Mice, Inbred C3H
Mutation
Organ Specificity
Polyomavirus
Virus Replication

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.