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Article

Mutations of polyomavirus VP1 allow in vitro growth in undifferentiated cells and modify in vivo tissue replication specificity.

Journal of virology - 1 Feb 1994

Mezes B, Amati P

Abstract excerpt

Mutants of polyomavirus with altered host specificities were isolated in undifferentiated C2 myoblast cells (L. Ricci, R. Maione, C. Passananti, A. Felsani, and P. Amati, J. Virol. 66:7153-7158, 1992). The mutations responsible for this phenotype belonged to either of the two classes: a large duplication of the enhancer region or a 6-bp deletion in the VP1 coding region. Since both classes of mutations enabled...

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Identifiers

PMID: 8289350
DOI: 10.1128/JVI.68.2.1196-1199.1994
PMCID: PMC236560

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