The transformation-defective adenovirus 12 host range mutant CS-1 lacks the E1a-specific 9.5S mRNA and contains a second deletion in E1b.

doi:10.1159/000150253

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Article

The transformation-defective adenovirus 12 host range mutant CS-1 lacks the E1a-specific 9.5S mRNA and contains a second deletion in E1b.

Intervirology - 1 Jan 1992

Opalka B, Reith-Witowski M, Roy A, Gnauck J, Schulte Holthausen H

Abstract excerpt

We have further analyzed structure and expression of the E1 region of the transformation-defective adenovirus 12 (Ad12) host range mutant CS-1. Using cDNA polymerase chain reaction analysis, the E1a region was found to give raise to five transcripts analogous to the Ad12wt 13S, 12S, 11S, 10S spec...

Topics

Adenovirus Early Proteins
Base Sequence
Cell Transformation, Neoplastic
Chromosome Deletion
Molecular Sequence Data
Mutation
Oncogene Proteins, Viral
RNA, Messenger

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