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Article

A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4

1 Sept 1996

Abstract excerpt

The improvements to adenovirus necessary for an optimal gene transfer vector include the removal of virus gene expression in transduced cells, increased transgene capacity, complete replication incompetence, and elimination of replication-competent virus that can be produced during the growth of first-generation adenovirus vectors. To achieve these aims, we have developed a vector-cell line system for complete...

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PMID: 8709289
DOI: 10.1128/jvi.70.9.6497-6501.1996

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