Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.

doi:10.1128/JVI.72.1.366-379.1998

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Article

Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant.

Journal of virology - 1 Jan 1998

Greaves R F, Mocarski E S

Abstract excerpt

To investigate the importance of the IE1 p72 regulatory protein during human cytomegalovirus replication, a recombinant virus unable to synthesize IE1 p72 was constructed. The Towne strain mutant CR208 lacked exon 4 of the major immediate-early gene and was isolated and complemented in an IE1-exp...

Topics

Antigens, Viral
Base Sequence
Cells, Cultured
Cytomegalovirus
DNA Primers
DNA Replication
DNA-Binding Proteins
Exons
Genes, Immediate-Early
Humans
Immediate-Early Proteins
Introns
Mutation
Open Reading Frames
Recombination, Genetic
Viral Proteins
Virus Replication

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Identifiers

PMID: 9420235
DOI: 10.1128/JVI.72.1.366-379.1998
PMCID: PMC109384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9420235-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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