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Article

Differential requirement for adenovirus type 12 E1A gene products in oncogenic transformation.

Journal of virology - 1 Oct 1990

Lamberti C, Williams J

Abstract excerpt

During the early period of infection, adenovirus type 12 E1A gene is expressed as overlapping, spliced mRNAs of 12 and 13S, which encode in-frame proteins of 235 and 266 amino acid residues (235R and 266R), respectively. To define the functions of these related products in the infection of human cells and transformation of rodent cells, we created single T-to-C transitions at the second base of each mRNA intron...

Topics

Adenovirus Early Proteins
Adenoviruses, Human
Animals
Cell Division
Cell Line
Cell Transformation, Neoplastic
DNA-Binding Proteins
Humans
Kinetics
Mutation
Oncogene Proteins, Viral

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Identifiers

PMID: 2144595
DOI: 10.1128/JVI.64.10.4997-5007.1990
PMCID: PMC247991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144595-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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