Article
Identification of specific amino acid residues of adenovirus 12 E1A involved in transformation and p300 binding.
Virus genes - 1 Jan 1997
Sawada Y, Ishino M, Miura K, Ohtsuka E, Fujinaga K
Abstract excerpt
The early region 1A (E1A) gene of highly oncogenic adenovirus type 12 (Ad12) was analyzed for transforming activity and protein binding using specific mutations. The Ad12 E1A proteins were found to bind p300 protein mainly within the CR1 region, although mutations that affect both p300 binding an...
Topics
- Adenovirus E1A Proteins
- Adenoviruses, Human
- Animals
- Binding Sites
- Cell Line
- Cell Transformation, Viral
- E1A-Associated p300 Protein
- Gene Expression Regulation
- HeLa Cells
- Humans
- Mutation
- Nuclear Proteins