Article
Apolipoprotein E genotype in patients with Alzheimer's disease: implications for the risk of dementia among relatives.
Annals of neurology - 1 Nov 1995
Farrer L A, Cupples L A, van Duijn C M, Kurz A, Zimmer R, Müller U, Green R C, Clarke V, Shoffner J, Wallace D C
Abstract excerpt
Numerous studies have shown that the risk of Alzheimer's disease (AD) is associated with the dose of the epsilon 4 allele of apolipoprotein E (ApoE). However, more than one third of AD patients lack epsilon 4 and many persons having epsilon 4 survive cognitively intact to old age. We evaluated the lifetime risk of disease in 3,999 first-degree relatives of 549 probands who met the criteria for probable or...
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