Article
Apolipoprotein E genotype in patients with Alzheimer's disease: implications for the risk of dementia among relatives.
Annals of neurology - 1 Nov 1995
Farrer L A, Cupples L A, van Duijn C M, Kurz A, Zimmer R, Müller U, Green R C, Clarke V, Shoffner J, Wallace D C
Abstract excerpt
Numerous studies have shown that the risk of Alzheimer's disease (AD) is associated with the dose of the epsilon 4 allele of apolipoprotein E (ApoE). However, more than one third of AD patients lack epsilon 4 and many persons having epsilon 4 survive cognitively intact to old age. We evaluated th...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- Cohort Studies
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Proportional Hazards Models
- Risk Factors
- Sensitivity and Specificity