Article
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
Science (New York, N.Y.) - 13 Aug 1993
Corder E H, Saunders A M, Strittmatter W J, Schmechel D E, Gaskell P C, Small G W, Roses A D, Haines J L, Pericak-Vance M A
Abstract excerpt
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alle...
Topics
- Aged
- Aged, 80 and over
- Aging
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Female
- Gene Frequency
- Genotype
- Homozygote
- Humans
- Linkage Disequilibrium
- Male
- Risk Factors
- Survival Rate