Article
Genetic variation detected by quantitative analysis of end-labeled genomic DNA fragments.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994
Asakawa J, Kuick R, Neel J V, Kodaira M, Satoh C, Hanash S M
Abstract excerpt
The continuing efforts to evaluate specific human populations for altered germinal mutation rates would profit from more efficient and more specific approaches than those of the past. To this end, we have explored the potential usefulness of two-dimensional electrophoresis of DNA fragments obtained from restriction-enzyme-digested genomic DNA. This permits the analysis, on a single preparation, of approximately...
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