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Article

High yield of restriction fragment length polymorphisms in two-dimensional separations of human genomic DNA.

Genomics - 20 Jan 1995

Kuick R, Asakawa J, Neel J V, Satoh C, Hanash S M

Abstract excerpt

We have investigated the extent to which restriction fragment length polymorphism can be detected by two-dimensional electrophoresis of end-labeled genomic restriction fragments. Genomic DNA was digested with NotI and EcoRV and labeled at the NotI recognition site before first-dimension electrophoresis in disk gels. DNA in the disk gels was further digested in situ with HinfI prior to second-dimension...

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PMID: 7789966
DOI: 10.1016/0888-7543(95)80032-h

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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