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Article

High yield of restriction fragment length polymorphisms in two-dimensional separations of human genomic DNA.

Genomics - 20 Jan 1995

Kuick R, Asakawa J, Neel J V, Satoh C, Hanash S M

Abstract excerpt

We have investigated the extent to which restriction fragment length polymorphism can be detected by two-dimensional electrophoresis of end-labeled genomic restriction fragments. Genomic DNA was digested with NotI and EcoRV and labeled at the NotI recognition site before first-dimension electrophoresis in disk gels. DNA in the disk gels was further digested in situ with HinfI prior to second-dimension...

Topics

Adult
Alleles
Base Sequence
Cell Line, Transformed
Child
DNA
Deoxyribonucleases, Type II Site-Specific
Electrophoresis, Gel, Two-Dimensional
Female
Gene Frequency
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Image Processing, Computer-Assisted

Male

Molecular Sequence Data

Pedigree

Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 7789966
DOI: 10.1016/0888-7543(95)80032-h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7789966-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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