DNA variation in a 5-Mb region of the X chromosome and estimates of sex-specific/type-specific mutation rates.

doi:10.1086/302250

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Article

DNA variation in a 5-Mb region of the X chromosome and estimates of sex-specific/type-specific mutation rates.

American journal of human genetics - 1 Feb 1999

Anagnostopoulos T, Green P M, Rowley G, Lewis C M, Giannelli F

Abstract excerpt

We describe a new approach for the study of human genome variation, based on our solid-phase fluorescence chemical mismatch-cleavage method. Multiplex screening rates >/=80 kb/36-lane gels are achieved, and accuracy of mismatch location is within +/-2 bp. The density of differences between DNA fr...

Topics

Animals
Base Sequence
DNA
Genetic Variation
Humans
Male
Molecular Sequence Data
Mutation
Pan troglodytes
Sex Factors
X Chromosome
Y Chromosome

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