Article
Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Aug 1997
Mansukhani M M, Nastiuk K L, Hibshoosh H, Kularatne P, Russo D, Krolewski J J
Abstract excerpt
The ability to identify individuals who are predisposed to specific malignant tumors is a promising molecular diagnostic by-product of over two decades of intensive research into the genetic pathogenesis of human cancer. Approximately 2% of Ashkenazi Jews carry recurrent germline mutations in eit...
Topics
- Alleles
- BRCA2 Protein
- Breast Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Electrophoresis, Polyacrylamide Gel
- Female
- Gene Amplification
- Genes, BRCA1
- Humans
- Loss of Heterozygosity
- Microscopy, Fluorescence
- Mutation
- Neoplasm Proteins