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Article

Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.

Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Aug 1997

Mansukhani M M, Nastiuk K L, Hibshoosh H, Kularatne P, Russo D, Krolewski J J

Abstract excerpt

The ability to identify individuals who are predisposed to specific malignant tumors is a promising molecular diagnostic by-product of over two decades of intensive research into the genetic pathogenesis of human cancer. Approximately 2% of Ashkenazi Jews carry recurrent germline mutations in either the BRCA1 or BRCA2 genes that may predispose these individuals to the development of breast and ovarian cancer. We...

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Source

Identifiers

PMID: 9360844
DOI: 10.1097/00019606-199708000-00007

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.PMID 9360844Read ↗

A rapid fluorescent multiplexed-PCR analysis (FMPA) for founder mutations in the BRCA1 and BRCA2 genes.Semantic proximity Read ↗

One step direct detection of recurrent mutations in the breast cancer susceptibility gene, BRCA1.Semantic proximity Read ↗

A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals.Semantic proximity Read ↗

Frequency and carrier risk associated with common BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer patients.Semantic proximity Read ↗

Detection of BRCA1 and BRCA2 Ashkenazi Jewish founder mutations in formalin-fixed paraffin-embedded tissues using conventional PCR and heteroduplex/amplicon size differences.Semantic proximity Read ↗

High throughput fluorescence-based conformation-sensitive gel electrophoresis (F-CSGE) identifies six unique BRCA2 mutations and an overall low incidence of BRCA2 mutations in high-risk BRCA1-negative breast cancer families.Semantic proximity Read ↗

A rapid and sensitive approach to mutation detection using real-time polymerase chain reaction and melting curve analyses, using BRCA1 as an example.Semantic proximity Read ↗

Direct detection of mutations in the breast and ovarian cancer susceptibility gene BRCA1 by PCR-mediated site-directed mutagenesis.Semantic proximity Read ↗

Denaturing high-performance liquid chromatography detects reliably BRCA1 and BRCA2 mutations.Semantic proximity Read ↗

Selective loss of heterozygosity in multiple breast cancers from a carrier of mutations in both BRCA1 and BRCA2.Semantic proximity Read ↗

Detection of DNA variation in cancer.Semantic proximity Read ↗

Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis.Semantic proximity Read ↗

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