Two-dimensional DNA typing of human pedigrees: spot pattern characterization and segregation.

doi:10.1006/geno.1995.9955

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Article

Two-dimensional DNA typing of human pedigrees: spot pattern characterization and segregation.

Genomics - 10 Oct 1995

Mullaart E, Verwest A M, Børglum A D, Uitterlinden A G, te Meerman G J, Kruse T A, Vijg J

Abstract excerpt

By two-dimensional (2-D) genome typing, i.e., electrophoretic separation of restriction enzyme-digested genomic DNA on the basis of both size and sequence in denaturing gradient gels followed by hybridization analysis, several hundred alleles (spots) can be analyzed in parallel, using a micro- or...

Topics

Alleles
Child
DNA
DNA Probes
Female
Genetic Variation
Genome, Human
Homozygote
Humans
Male
Pedigree
Restriction Mapping

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