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Article

PCR-generated padlock probes distinguish homologous chromosomes through quantitative fluorescence analysis.

European journal of human genetics : EJHG - 1 May 2003

Antson Dan-Oscar, Mendel-Hartvig Maritha, Landegren Ulf, Nilsson Mats

Abstract excerpt

Conventional cytogenetic techniques can distinguish homologous chromosomes in a qualitative manner based upon obvious morphological features or using in situ hybridization methods that yield qualitative data. We have developed a method for quantitative genotyping of single-nucleotide variants in situ using circularizable DNA probes, so-called padlock probes, targeting two different alpha satellite repeat variants...

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PMID: 12734539
DOI: 10.1038/sj.ejhg.5200966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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