Article
Differential effect of p53 on the promoters of mouse DNA polymerase beta gene and proliferating-cell-nuclear-antigen gene.
European journal of biochemistry - 1 Apr 1994
Yamaguchi M, Hayashi Y, Matsuoka S, Takahashi T, Matsukage A
Abstract excerpt
A plasmid carrying the 5' flanking region of the mouse proliferating-cell-nuclear-antigen (PCNA) gene or DNA polymerase beta gene was fused with the chloramphenicol acetyltransferase (CAT) gene, then cotransfected into mouse N18TG2 cells with the expression plasmid for the p53 gene. Expression of the wild-type p53 repressed the CAT expression directed by the PCNA gene promoter, while it had little effect on the...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Chloramphenicol O-Acetyltransferase
- DNA Polymerase I
- Mice
- Molecular Sequence Data
- Mutation
- Neuroblastoma
- Nuclear Proteins
- Plasmids