Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.

doi:10.1073/pnas.93.2.895

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Article

Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jan 1996

Morris G F, Bischoff J R, Mathews M B

Abstract excerpt

Proliferating-cell nuclear antigen (PCNA) is a DNA damage-inducible protein that performs an essential function in DNA replication and repair as an auxiliary factor for DNA polymerases delta and epsilon. Examination of the human PCNA promoter DNA sequence revealed a site with homology to the cons...

Topics

Base Sequence
Cells, Cultured
Chloramphenicol O-Acetyltransferase
DNA Damage
Gene Expression Regulation
Humans
Li-Fraumeni Syndrome
Molecular Sequence Data
Mutation
Proliferating Cell Nuclear Antigen
Promoter Regions, Genetic
Protein Binding
Recombinant Fusion Proteins
Transcription, Genetic
Transfection
Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 8570655
DOI: 10.1073/pnas.93.2.895
PMCID: PMC40154

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8570655-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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