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Article

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein.

Molecular and cellular biology - 1 Mar 1993

Foord O, Navot N, Rotter V

Abstract excerpt

Wild-type p53 was shown to function as a transcription factor. The N-terminal region of the protein contains the transcription activation domain, while the C terminus is responsible for DNA binding. Localization of the DNA-binding domain of the p53 protein to the highly conserved carboxy-terminal region suggests that the interaction of p53 with DNA is important for its function. We have developed a strategy for...

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Identifiers

PMID: 8441383
DOI: 10.1128/mcb.13.3.1378-1384.1993
PMCID: PMC359447

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Source receipt: pubmed, retrieved 7 Sept 2026.

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