Article
Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein.
Molecular and cellular biology - 1 Mar 1993
Foord O, Navot N, Rotter V
Abstract excerpt
Wild-type p53 was shown to function as a transcription factor. The N-terminal region of the protein contains the transcription activation domain, while the C terminus is responsible for DNA binding. Localization of the DNA-binding domain of the p53 protein to the highly conserved carboxy-terminal...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- Chloramphenicol O-Acetyltransferase
- Cloning, Molecular
- DNA
- DNA, Recombinant
- Deoxyribonuclease I
- Escherichia coli
- Genome
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Promoter Regions, Genetic
- Transcription Factors
- Transcriptional Activation