Article
Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells.
Journal of virology - 1 Oct 1992
Deb S, Jackson C T, Subler M A, Martin D W
Abstract excerpt
Wild-type p53 has recently been shown to repress transcription from several cellular and viral promoters. Since p53 mutations are the most frequently reported genetic defects in human cancers, it becomes important to study the effects of mutations of p53 on promoter functions. We, therefore, have...
Topics
- Activating Transcription Factors
- Avian Sarcoma Viruses
- Base Sequence
- Blood Proteins
- Chloramphenicol O-Acetyltransferase
- Cyclic AMP Response Element-Binding Protein
- Cytomegalovirus
- DNA-Binding Proteins
- HeLa Cells
- Human T-lymphotropic virus 1
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins