Article
p53 transactivation through various p53-responsive elements.
Molecular carcinogenesis - 1 Jun 1996
Park D J, Chumakov A M, Miller C W, Pham E Y, Koeffler H P
Abstract excerpt
p53 is a nuclear phosphoprotein whose function is classified as tumor suppression. Studies have shown that p53 functions by binding to p53 DNA recognition sequences and regulates transcription of growth-regulatory genes. Various p53 recognition sequences have recently been identified. pOST2 contained two copies of a palindromic high-affinity DNA-binding sequence for p53; the other p53 recognition sequences...
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