p53 transactivation through various p53-responsive elements.

doi:10.1002/(SICI)1098-2744(199606)16:2<101::AID-MC6>3.0.CO;2-L

Back to search

Article

p53 transactivation through various p53-responsive elements.

Molecular carcinogenesis - 1 Jun 1996

Park D J, Chumakov A M, Miller C W, Pham E Y, Koeffler H P

Abstract excerpt

p53 is a nuclear phosphoprotein whose function is classified as tumor suppression. Studies have shown that p53 functions by binding to p53 DNA recognition sequences and regulates transcription of growth-regulatory genes. Various p53 recognition sequences have recently been identified. pOST2 conta...

Topics

Base Sequence
Carcinoma
Chloramphenicol O-Acetyltransferase
Codon
Humans
Molecular Sequence Data
Mutation
Neuroblastoma
Regulatory Sequences, Nucleic Acid
Transcription, Genetic
Transcriptional Activation
Transfection
Tumor Cells, Cultured
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.