Article
DNA damage response of cloned DNA beta-polymerase promoter is blocked in mutant cell lines deficient in protein kinase A.
Nucleic acids research - 11 Nov 1992
Englander E W, Wilson S H
Abstract excerpt
DNA beta-polymerase (beta-pol), one of the recognized DNA polymerizing enzymes in vertebrates, has a role in 'very short patch' gap-filling synthesis during nucleotide excision DNA repair. In human and mouse, the enzyme is encoded by a single-copy gene located on the short arm of chromosome 8 near the centromere. In a series of studies, we have found that the cloned human beta-pol promoter is regulated by signals...
Topics
- Animals
- Base Sequence
- CHO Cells
- Cell Line
- Cricetinae
- DNA
- DNA Damage
- DNA Polymerase I
- Humans
- Methylnitronitrosoguanidine
- Molecular Sequence Data
- Mutation