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Article

Wild-type p53 down-regulates transcription from oncogenic human papillomavirus promoters through the epithelial specific enhancer.

Oncogene - 1 Jun 1995

Desaintes C, Hallez S, Detremmerie O, Burny A

Abstract excerpt

High-risk Human Papillomavirus (HPV) E6 and E7 immortalizing oncoproteins are expressed from a promoter tightly regulated by an epithelial specific enhancer. To determine if the p53 tumour suppressor protein can modulate the transcription of these genes, we performed co-transfection experiments with plasmids containing the HPV type 16 or 18 long control regions linked to the chloramphenicol acetyl transferase...

Topics

Cell Line
Down-Regulation
Enhancer Elements, Genetic
Epithelium
HeLa Cells
Humans
Mutation
Papillomaviridae
Promoter Regions, Genetic
Transcription, Genetic
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7784059

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7784059-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Wild-type p53 down-regulates transcription from oncogenic human papillomavirus promoters through the epithelial specific enhancer.PMID 7784059Read ↗

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