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Article

Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.

1 Sept 1991

Abstract excerpt

The aberrant overexpression of interleukin 6 (IL-6) is implicated as an autocrine mechanism in the enhanced proliferation of the neoplastic cell elements in various B- and T-cell malignancies and in some carcinomas and sarcomas; many of these neoplasms have been shown to be associated with a mutated p53 gene. The possibility that wild-type (wt) p53, a nuclear tumor-suppressor protein, but not its transforming...

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PMID: 1652755
DOI: 10.1073/pnas.88.17.7605

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Source receipt: pubmed, retrieved 7 Sept 2026.

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