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Article

Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor.

Molecular and cellular biology - 1 Jan 1997

Wang Q, Zambetti G P, Suttle D P

Abstract excerpt

DNA topoisomerase II (topo II) is an essential nuclear enzyme involved in major cellular functions such as DNA replication, transcription, recombination, and mitosis. While an elevated level of topo II alpha is associated with cell proliferation, wild-type (wt) p53 inhibits the expression of vari...

Topics

Animals
Antigens, Neoplasm
Cell Line
DNA Topoisomerases, Type II
DNA, Recombinant
DNA-Binding Proteins
Gene Expression Regulation, Enzymologic
Genes, p53
Humans
Isoenzymes
Mice
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

RNA, Messenger

Transcription, Genetic

Transfection

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 8972219
DOI: 10.1128/MCB.17.1.389
PMCID: PMC231763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8972219-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor.PMID 8972219Read ↗

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