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Article

Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor.

Molecular and cellular biology - 1 Jan 1997

Wang Q, Zambetti G P, Suttle D P

Abstract excerpt

DNA topoisomerase II (topo II) is an essential nuclear enzyme involved in major cellular functions such as DNA replication, transcription, recombination, and mitosis. While an elevated level of topo II alpha is associated with cell proliferation, wild-type (wt) p53 inhibits the expression of various growth-stimulatory genes. To determine if p53 downregulates topo II alpha gene expression, a murine cell line,...

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Identifiers

PMID: 8972219
DOI: 10.1128/MCB.17.1.389
PMCID: PMC231763

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor.PMID 8972219Read ↗

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