Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.

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Article

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.

Oncogene - 1 May 1994

Qian X, Dougall W C, Hellman M E, Greene M I

Abstract excerpt

p185c-neu and epidermal growth factor receptor (EGFR) associate into an active heterodimer, and overexpression of these two receptors leads to a transformed phenotype. However, the association of EGFR and kinase-deficient Neu proteins (point mutant N757 or cytoplasmic domain deletion mutant N691s...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
DNA
Dose-Response Relationship, Drug
Down-Regulation
Epidermal Growth Factor
ErbB Receptors
Fibroblasts
Half-Life
Mice
Mice, Nude
Phenotype
Point Mutation
Proto-Oncogene Proteins
Receptor, ErbB-2

Source

Open in PubMed

Identifiers

PMID: 7908733

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7908733-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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