Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins.

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Article

Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins.

Oncogene - 1 Apr 1990

Wada T, Myers J N, Kokai Y, Brown V I, Hamuro J, LeVea C M, Greene M I

Abstract excerpt

The neu oncogene product, p185neu, is a tyrosine kinase receptor with structural similarity to the epidermal growth factor (EGF) receptor. We have recently described that coexpression of EGF receptors and high levels of normal p185c-neu lead to transformation of rodent fibroblasts. Anti-EGF receptor and anti-p185neu monoclonal antibodies inhibited tumorigenic growth of these transformants implanted into nude...

Topics

Animals
Antibodies, Monoclonal
Cell Division
Cell Line
Cell Transformation, Neoplastic
DNA Replication
ErbB Receptors
Kinetics
Mice
Mice, Nude
Neoplasm Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Experimental

Phenotype

Protein-Tyrosine Kinases

Proto-Oncogene Proteins

Proto-Oncogenes

Rats

Receptor, ErbB-2

Source

Open in PubMed

Identifiers

PMID: 1970151

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1970151-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Anti-receptor antibodies reverse the phenotype of cells transformed by two interacting proto-oncogene encoded receptor proteins.PMID 1970151Read ↗

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.Semantic proximity Read ↗

Domain-specific interactions between the p185(neu) and epidermal growth factor receptor kinases determine differential signaling outcomes.Semantic proximity Read ↗

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