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Article

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

Molecular and cellular biology - 1 Mar 1991

Kashles O, Yarden Y, Fischer R, Ullrich A, Schlessinger J

Abstract excerpt

Recent studies provide evidence that defective receptors can function as a dominant negative mutation suppressing the action of wild-type receptors. This causes various diminished responses in cell culture and developmental disorders in murine embryogenesis. Here, we describe a model system and a potential mechanism underlying the dominant suppressing response caused by defective epidermal growth factor (EGF)...

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Identifiers

PMID: 1705006
DOI: 10.1128/mcb.11.3.1454-1463.1991
PMCID: PMC369423

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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