Article
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.
Molecular and cellular biology - 1 Mar 1991
Kashles O, Yarden Y, Fischer R, Ullrich A, Schlessinger J
Abstract excerpt
Recent studies provide evidence that defective receptors can function as a dominant negative mutation suppressing the action of wild-type receptors. This causes various diminished responses in cell culture and developmental disorders in murine embryogenesis. Here, we describe a model system and a potential mechanism underlying the dominant suppressing response caused by defective epidermal growth factor (EGF)...
Topics
- Animals
- Cell Line
- DNA
- DNA Mutational Analysis
- Endocytosis
- Epidermal Growth Factor
- ErbB Receptors
- Genes, Dominant
- Genes, Suppressor
- Ligands
- Macromolecular Substances