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Article

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997

O'Rourke D M, Qian X, Zhang H T, Davis J G, Nute E, Meinkoth J, Greene M I

Abstract excerpt

Our aim has been to understand the features of erbB receptor homo- and heterodimer assembly to develop approaches to disrupt receptor activation. We have developed a general approach to cause erbB receptor-specific trans inhibition of human neoplasia. The clonal progression of human astrocytomas to a more malignant phenotype often involves the amplification and overexpression of the epidermal growth factor...

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Identifiers

PMID: 9096379
DOI: 10.1073/pnas.94.7.3250
PMCID: PMC20355

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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