Article
Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997
O'Rourke D M, Qian X, Zhang H T, Davis J G, Nute E, Meinkoth J, Greene M I
Abstract excerpt
Our aim has been to understand the features of erbB receptor homo- and heterodimer assembly to develop approaches to disrupt receptor activation. We have developed a general approach to cause erbB receptor-specific trans inhibition of human neoplasia. The clonal progression of human astrocytomas...
Topics
- Animals
- Cell Adhesion
- Cell Division
- DNA, Complementary
- ErbB Receptors
- Glioblastoma
- Humans
- Mice
- Mice, Nude
- Phenotype
- Receptor, ErbB-2
- Signal Transduction
- Transfection
- Tumor Cells, Cultured