Article
Growth inhibition by dominant-negative mutations of the neu-encoded oncoprotein.
International journal of cancer - 6 Jan 1997
Schlegel J, Trenkle T, Stumm G, Kiessling M
Abstract excerpt
In the present study, kinase-deficient mutants of the neu gene were constructed in order to generate dominant-negative receptor molecules, which should abolish phosphorylation of receptor complexes. One construct carried a mutation of the putative ATP-binding site (K758M), while the other mutant...
Topics
- 3T3 Cells
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Humans
- Mice
- Mutation
- Phosphorylation
- Rats
- Receptor, ErbB-2
- Transfection