Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain.

Oncogene - 11 Feb 2010

Ozer B H, Wiepz G J, Bertics P J

Abstract excerpt

A mutation of the epidermal growth factor receptor (EGFR) that results in a tandem kinase domain duplication (TKD-EGFR) has been described in glioblastoma multiforme biopsies and cell lines. Although the TKD-EGFR confers tumorigenicity, little is known about the molecular underpinnings of receptor dysregulation. Therefore, we transfected B82L mouse fibroblast cells devoid of endogenous EGFR to determine the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Gene Knockout Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glioblastoma

Share to Ligands

Share to Oncogenes

Share to Protein Multimerization

Share to Protein Structure, Quaternary

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 19915609
DOI: 10.1038/onc.2009.385
PMCID: PMC2820599

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain.PMID 19915609Read ↗

Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targetingSemantic proximity Read ↗

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism.Semantic proximity Read ↗

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.Semantic proximity Read ↗

Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.Semantic proximity Read ↗

Roles for receptor tyrosine kinases in tumor progression and implications for cancer treatment.Semantic proximity Read ↗

Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor.Semantic proximity Read ↗

Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis.Semantic proximity Read ↗

Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspectiveSemantic proximity Read ↗

Epidermal growth factor receptor as a therapeutic target in glioblastoma.Semantic proximity Read ↗

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse modelsSemantic proximity Read ↗

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse modelsSemantic proximity Read ↗

Activation of extracellular-regulated kinases by normal and mutant EGF receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.