Article
Frequent allelic deletion at a novel locus on chromosome 5 in human lung cancer.
Cancer research - 1 Apr 1994
Wieland I, Böhm M
Abstract excerpt
Frequent allelic deletions in tumor cells are indicative of the inactivation of tumor suppressor genes. Recently, we isolated the single-copy sequence del-27 (I. Wieland, M. Böhm, and S. Bogatz, Proc. Natl. Acad. Sci. USA, 89: 9705-9709, 1992). Here we show that del-27 detects a restriction fragm...
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Cricetinae
- DNA Primers
- Deoxyribonuclease HindIII
- Gene Deletion
- Genes, APC
- Genes, Tumor Suppressor
- Humans
- Hybrid Cells
- Lung Neoplasms
- Molecular Sequence Data
- Polymerase Chain Reaction