Article
Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer.
Cancer research - 15 Jun 1998
Burke L, Khan M A, Freedman A N, Gemma A, Rusin M, Guinee D G, Bennett W P, Caporaso N E, Fleming M V, Travis W D, Colby T V, Trastek V, Pairolero P C, Tazelaar H D, Midthun D E, Liotta L A, Harris C C
Abstract excerpt
The fragile histidine triad (FHIT) gene at chromosome 3p14.2 is a candidate tumor suppressor gene linked to cancers of the lung, breast, colon, pancreas, and head and neck. Reports of frequent allelic deletion and abnormal transcripts in primary lung tumors plus recent evidence that it is targeted by tobacco smoke carcinogens suggest that it plays an important role in lung carcinogenesis. Non-small cell lung...
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