Article
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types.
Genes, chromosomes & cancer - 1 Apr 1998
Virmani A K, Fong K M, Kodagoda D, McIntire D, Hung J, Tonk V, Minna J D, Gazdar A F
Abstract excerpt
Allelic loss is a hallmark of tumor suppressor gene (TSG) inactivation. We have allelotyped 29 paired lymphoblastoid and lung cancer cell lines derived from 11 patients with small cell (SCLC) and 18 patients with non-small cell lung carcinomas (NSCLC). Statistical analysis indicated that a thresh...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Chromosome Deletion
- Chromosomes, Human, 1-3
- Chromosomes, Human, 13-15
- Chromosomes, Human, 19-20
- Chromosomes, Human, 21-22 and Y
- Chromosomes, Human, 4-5
- Chromosomes, Human, 6-12 and X
- Female
- Genotype
- Humans
- Loss of Heterozygosity