Article
Identification of a novel tumor suppressor gene p34 on human chromosome 6q25.1.
Cancer research - 1 Jan 2007
Wang Min, Vikis Haris G, Wang Yian, Jia Dongmei, Wang Daolong, Bierut Laura J, Bailey-Wilson Joan E, Amos Christopher I, Pinney Susan M, Petersen Gloria M, de Andrade Mariza, Yang Ping, Wiest Jonathan S, Fain Pamela R, Schwartz Ann G, Gazdar Adi, Minna John, Gaba Colette, Rothschild Henry, Mandal Diptasri, Kupert Elena, Seminara Daniela, Liu Yan, Viswanathan Avinash, Govindan Ramaswamy, Anderson Marshall W, You Ming
Abstract excerpt
In this study, we observed loss of heterozygosity (LOH) in human chromosomal fragment 6q25.1 in sporadic lung cancer patients. LOH was observed in 65% of the 26 lung tumors examined and was narrowed down to a 2.2-Mb region. Single-nucleotide polymorphism (SNP) analysis of genes located within this region identified a candidate gene, termed p34. This gene, also designated as ZC3H12D, C6orf95, FLJ46041, or...
Topics
- Alleles
- Animals
- Base Sequence
- Chromosomes, Human, Pair 6
- Codon
- Female
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Humans