Article
Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung.
Oncogene - 30 Jul 1998
Petersen S, Rudolf J, Bockmühl U, Gellert K, Wolf G, Dietel M, Petersen I
Abstract excerpt
The genetic mechanisms underlying the progression to the metastatic phenotype of lung cancer are poorly understood. We recently showed that small cell lung cancer (SCLC) and metastasizing squamous cell carcinomas are characterized by an increased incidence of allelic loss on chromosome 10q. In th...
Topics
- Alleles
- Carcinoma, Squamous Cell
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- Genes, Tumor Suppressor
- Humans
- Loss of Heterozygosity
- Lung Neoplasms
- Microsatellite Repeats
- PTEN Phosphohydrolase
- Phosphoric Monoester Hydrolases
- Protein Tyrosine Phosphatases
- Tumor Cells, Cultured
- Tumor Suppressor Proteins