Article
Mutations in the coding region of c-myc occur independently of mutations in the regulatory regions and are predominantly associated with myc/Ig translocation.
Current topics in microbiology and immunology - 1 Jan 1995
Bhatia K, Spangler G, Hamdy N, Neri A, Brubaker G, Levin A, Magrath I
Abstract excerpt
Constitutive expression of c-myc resulting from a chromosomal translocation, which juxtaposes c-myc to an immunoglobulin gene, is a pivotal lesion in Burkitt's lymphomas. This deregulated expression of c-myc is associated with mutations in the regulatory regions, i.e. the first exon and the first intron of c-myc in tumors where the chromosomal breakpoint is not itself within the regulatory region. Until recently...
Topics
- Burkitt Lymphoma
- Chromosomes, Human, Pair 8
- DNA Mutational Analysis
- DNA, Neoplasm
- Genes, Immunoglobulin
- Genes, myc
- Herpesviridae Infections
- Herpesvirus 4, Human
- Humans
- Immunoglobulin Heavy Chains