Article
Infrequent p53 mutation in mouse tumors with deregulated myc.
Cancer research - 15 Feb 1992
Gutierrez M I, Bhatia K, Siwarski D, Wolff L, Magrath I T, Mushinski J F, Huppi K
Abstract excerpt
An invariant genetic lesion in mouse plasmacytomas is deregulated expression of c-myc as a consequence of chromosomal translocation. However, retroviral and transgenic studies suggest that additional genetic lesions may contribute to the genesis of plasmacytomas. The p53 tumor suppressor gene is a likely contributor to this genetic lesion, since there is a high incidence of p53 mutation in Burkitt's lymphomas and...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Exons
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Genes, p53
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation