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Article

Infrequent p53 mutation in mouse tumors with deregulated myc.

Cancer research - 15 Feb 1992

Gutierrez M I, Bhatia K, Siwarski D, Wolff L, Magrath I T, Mushinski J F, Huppi K

Abstract excerpt

An invariant genetic lesion in mouse plasmacytomas is deregulated expression of c-myc as a consequence of chromosomal translocation. However, retroviral and transgenic studies suggest that additional genetic lesions may contribute to the genesis of plasmacytomas. The p53 tumor suppressor gene is a likely contributor to this genetic lesion, since there is a high incidence of p53 mutation in Burkitt's lymphomas and...

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PMID: 1737333

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Infrequent p53 mutation in mouse tumors with deregulated myc.PMID 1737333Read ↗

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The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.Semantic proximity Read ↗

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